Leukemic phase of ALK-positive anaplastic large cell lymphoma.
نویسندگان
چکیده
A 25-year-old woman presented with lymphadenopathy. Peripheral blood showed leukocytosis, anemia, and thrombocytopenia (white blood cell count, 102.9 3 10/L; hemoglobin level, 76 g/L; and platelet count, 32 3 10/L). Peripheral smear demonstrated a predominant population of large cells with reticular chromatin, folded to irregular nuclear contours, and abundant basophilic cytoplasm. Many cells contained cytoplasmic vacuoles. By flow cytometry, these cells were within the monocyte gate (CD45/side scatter) and expressed the myeloid-associated marker CD13, in addition to CD56, HLA-DR, CD5, CD7 (partial), and cytoplasmic CD3 (dim). They were negative for CD33, CD34, CD117, CD19, CD3, CD4, and CD8. Cytochemically, the cells were negative for butyrate and chloroacetate esterases. A lymph node biopsy showed ALK-positive anaplastic large cell lymphoma (ALCL). Peripheral blood fluorescence in situ hybridization demonstrated ALK gene rearrangement in 97.5% of nuclei, confirming a leukemic phase of the ALK-positive ALCL.
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عنوان ژورنال:
- Blood
دوره 121 11 شماره
صفحات -
تاریخ انتشار 2013